Immune cell response
Th17 immune cells are elevated, leading to the overproduction of proinflammatory cytokines such
as IL-17A and IL-17F.2,15
EXPLORING THE
MECHANISM OF DISEASE IN PLAQUE PSORIASIS14
Plaque psoriasis is a chronic, immune-mediated skin disorder where several mechanisms in the skin become dysregulated, leading to chronic inflammation and:
Skin barrier dysfunction
Proinflammatory cytokines promote excessive growth of keratinocytes and reduce production of
proteins that are essential for skin repair.16,17
Oxidative stress
Sustained inflammation causes excessive reactive oxygen species production, exacerbating
oxidative damage.18
WHAT’S THE ROLE OF THE ARYL HYDROCARBON RECEPTOR
(AHR) IN PLAQUE PSORIASIS?2
AhR is a ligand-dependent transcription factor that regulates diverse, multifunctional pathways. It plays an important balancing role in skin homeostasis.
AhR signaling could help restore order and balance to the dysregulated mechanisms in plaque psoriasis because:
-
AhR suppresses Th17 cell growth and production of key cytokines, such as IL-17 and IL-2214
-
AhR upregulates the production of skin barrier proteins to restore skin barrier function2
-
AhR induces the Nrf2 transcription factor pathway to increase antioxidant activity19
THE SCIENCE BEHIND TAPINAROF
The specific mechanisms by which VTAMA® (tapinarof) cream, 1% exerts its therapeutic action in patients with psoriasis are unknown. The Aryl hydrocarbon Receptor (AhR) is a ligand-dependent transcription factor that helps regulate diverse pathways, like decreasing inflammation, reducing oxidative stress, and normalizing skin barrier functions. Tapinarof, in VTAMA cream, supports these natural pathways.2,14
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