STARTING AS EARLY AS 4 WEEKS
PATIENTS ACHIEVED SIGNIFICANTLY CLEARER SKIN WITH VTAMA CREAM1,6-8
VTAMA® (tapinarof) cream, 1% achieved 6x treatment success* rate vs vehicle at week 12 with significant efficacy results seen as early as week 4.
Patients achieved 36% and 40% treatment success* in the VTAMA cream arms vs 6% and 6%
in the vehicle arms in PSOARING 1 and 2 pivotal studies1
*Treatment success: PGA score of 0 or 1 and ≥2-grade improvement from baseline at week 12.6
VTAMA CREAM DEMONSTRATED CLEARER SKIN OVER 12 WEEKS
In two identical studies, VTAMA cream showed significant results vs vehicle at week 4 with
improvements continuing over 12 weeks1,7-9
Not an actual patient
PGA treatment success: PGA Score of 0 or 1 and
≥2-grade improvement from baseline to week 121,6-8
VTAMA CREAM delivered significant PASI75 rates as early as week 4, with
continued improvement through week 129
At week 12, up to 48% of VTAMA cream patients achieved PASI75 vs ~10% of those using
vehicle9
PASI75 from Baseline to week 12 (ITT, MI)6,9
ITT, intention-to-treat; MI, multiple imputation; PASI75, ≥75% improvement in Psoriasis Area and Severity
Index; QD, once daily; SEM, standard error of mean.
Itch response significantly improved as early as week 2 and maintained through week 12 (ITT,
OC)10
- Up to ~68% of VTAMA cream patients achieved a minimum 4-point improvement in PP-NRS* vs 46% on vehicle at week 1210
- PP-NRS data was a prospective Patient-Reported Outcome secondary endpoint
Minimum 4-point improvement in Peak Pruritus Numeric Rating Score (PP-NRS) from Baseline to Week 12 (ITT,
OC)†7,8,10
ITT, intention-to-treat; OC, observed cases.
*Peak Pruritus Numeric Rating Scale (PP-NRS) is a single, patient self-reported item. It is an 11-point scale ranging from “no itch” (0) to “worst itch possible” (10), to assess worst itch experienced in a 24-hour period.11
†In those patients with at least a 4-point Peak Pruritus NRS at baseline.7,8
‡Denotes statistical significance.7,8
*Peak Pruritus Numeric Rating Scale (PP-NRS) is a single, patient self-reported item. It is an 11-point scale ranging from “no itch” (0) to “worst itch possible” (10), to assess worst itch experienced in a 24-hour period.11
†In those patients with at least a 4-point Peak Pruritus NRS at baseline.7,8
‡Denotes statistical significance.7,8
SEE SIGNIFICANT RESULTS FROM PATIENTS IN VTAMA CREAM CLINICAL studies
VTAMA cream helped adult patients with mild, moderate, and severe plaque psoriasis achieve clearer
skin.
Click on each section of the body to view the results. Please note, the photographs you will see are representative of one target lesion on individual patients treated with VTAMA cream during the clinical studies.
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